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Lenalidomide in combination with R-CHOP in lymphoma
The Lancet Oncology, In Press, Corrected Proof, Available online 28 August 2014
Lenalidomide combined with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) shows activity in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL), new research suggests.
DLBCL has two major subtypes: germinal centre B-cell-like (GCB) and activated B-cell-like (ABC). Although R-CHOP is considered standard-of-care therapy for patients with newly diagnosed DLBCL, treatment outcomes for patients with ABC DLBCL are poor. Lenalidomide has shown significan ...