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Overexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemia

Blood Cells, Molecules, and Diseases

Abstract

EZH2, a histone methyltransferase, is overexpressed in several human tumors, but whether it exerts any impact in chronic lymphocytic leukemia (CLL) remains unknown. We used real time PCR to investigate the expression profile of EZH1 and EZH2 in 59 CLL patients, 10 samples of purified B-cells from healthy donors and 12 normal adult tissues. EZH2 was overexpressed in CLL patients and correlates with high white blood cell count, ZAP-70 expression and chromosomal abnormalities. EHZ1 expression does not correlate with CLL progression. EZH2 overexpression is related to a poor prognosis of CLL and could be a useful tool to assess its aggressiveness.

Keywords: Chronic lymphocytic leukemia, EZH2, Histone methyltransferase, Gene expression, Cytogenetic.

Footnotes

a Laboratory of Molecular Pathology of Cancer, University of Brasília, Av. L2 Norte, Brasília, DF 70.910-900, Brazil

b Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP 14.048-900, Brazil

c Hospital de Base do Distrito Federal, Setor Hospitalar Sul, Área Especial, Quadra 101, Brasília, DF 70.330-150, Brazil

lowast Corresponding author. Fax: + 55 61 3107 2008.